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Related Experiment Video

Updated: Aug 6, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Second-trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth.

Louis Marcellin1,2,3, Frédéric Batteux1,3,4, Sandrine Chouzenoux1,3

  • 1Université Paris Cité, Paris, France.

Acta Obstetricia Et Gynecologica Scandinavica
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

Higher levels of extracellular matrix proteins like procollagen, osteopontin, IL-33, and cytokines IL-19 and TNFα in amniotic fluid during the second trimester may predict spontaneous preterm birth. These findings offer potential biomarkers for identifying at-risk pregnancies.

Keywords:
Mycoplasma hominisUreaplasma urealiticumIL-33amniotic fluidosteopontinpreterm birthprocollagensecond-trimester pregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Biology
  • Biochemistry

Background:

  • The pathogenesis of preterm labor is not fully understood.
  • Identifying biomarkers for spontaneous preterm delivery is crucial for early intervention.

Purpose of the Study:

  • To compare amniotic fluid concentrations of extracellular matrix-related proteins and cytokines in women with and without subsequent spontaneous preterm delivery.
  • To investigate potential biomarkers for predicting preterm birth.

Main Methods:

  • A nested case-control study was conducted using amniotic fluid samples from a randomized trial.
  • Samples were collected via amniocentesis between 16-20 weeks gestation and tested for infection (16S rDNA PCR).
  • Immunoassays were used to measure protein and cytokine concentrations in preterm and full-term delivery groups.

Main Results:

  • Amniotic fluid levels of procollagen, osteopontin, IL-19, IL-33, and TNFα were significantly higher in women who delivered preterm compared to those who delivered at full term.
  • No significant differences were observed in IL-6, IL-20, TGFβ, and IL-1β levels between the groups.

Conclusions:

  • Elevated second-trimester amniotic fluid concentrations of procollagen, osteopontin, IL-33, IL-19, and TNFα are associated with later spontaneous preterm birth.
  • These proteins and cytokines may serve as early indicators for predicting spontaneous preterm delivery.
  • Further research is warranted to validate these findings as predictive markers for preterm birth.