Related Experiment Video
Updated: Aug 6, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Avoiding background knowledge: literature based discovery from important information
1Information School, University of Sheffield, S1 4DP, Sheffield, UK. judita.preiss@sheffield.ac.uk.
Background:
Automatic literature based discovery attempts to uncover new knowledge by connecting existing facts: information extracted from existing publications in the form of [Formula: see text] and [Formula: see text] relations can be simply connected to deduce [Formula: see text]. However, using this approach, the quantity of proposed connections is often too vast to be useful. It can be reduced by using subject[Formula: see text](predicate)[Formula: see text]object triples as the [Formula: see text] relations, but too many proposed connections remain for manual verification.
Results:
Based on the hypothesis that only a small number of subject-predicate-object triples extracted from a publication represent the paper's novel contribution(s), we explore using BERT embeddings to identify these before literature based discovery is performed utilizing only these, important, triples. While the method exploits the availability of full texts of publications in the CORD-19 dataset-making use of the fact that a novel contribution is likely to be mentioned in both an abstract and the body of a paper-to build a training set, the resulting tool can be applied to papers with only abstracts available. Candidate hidden knowledge pairs generated from unfiltered triples and those built from important triples only are compared using a variety of timeslicing gold standards.
Conclusions:
The quantity of proposed knowledge pairs is reduced by a factor of [Formula: see text], and we show that when the gold standard is designed to avoid rewarding background knowledge, the precision obtained increases up to a factor of 10. We argue that the gold standard needs to be carefully considered, and release as yet undiscovered candidate knowledge pairs based on important triples alongside this work.
Related Concept Videos
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Drug Discovery: Overview
Cognitivism
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process...
Health Literacy
Structuralism
Titchener's approach to structuralism was unique. He...
Information Processing Approach

