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Research progress on non-protein-targeted drugs for cancer therapy

Yiwen Zhang1,2, Lu Lu1,2, Feifeng Song1

  • 1Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.

Journal of Experimental & Clinical Cancer Research : CR
|March 15, 2023
PubMed

Insights

RNA therapeutics, including oligonucleotide drugs and mRNA vaccines, show promise for treating hereditary diseases and cancer. Effective cancer treatment relies on selecting appropriate targets and optimizing delivery vehicles for RNA-based gene therapies.

Area of Science:

  • Biopharmaceuticals
  • Molecular Biology
  • Oncology

Background:

  • Non-protein target drugs, particularly RNA-based gene therapies, are gaining recognition for treating hereditary diseases.
  • Cancer remains a significant challenge with no current miracle drug.
  • Biopharmaceutical advancements are shifting cancer therapy research towards non-protein targets, especially RNA therapeutics.

Purpose of the Study:

  • To summarize clinical research progress in RNA therapeutics for cancer treatment.
  • To highlight key factors for enhancing the effectiveness of in vivo cancer therapy.

Main Methods:

  • Review of clinical research on RNA therapeutics.
  • Analysis of target selection and delivery vehicle optimization.

Main Results:

  • RNA therapeutics, including oligonucleotide drugs and mRNA vaccines, are a focus in cancer therapy research.
  • Appropriate target selection is crucial for effective RNA-based cancer treatment.
  • Optimized delivery vehicles are essential for enhancing in vivo efficacy of RNA therapeutics.

Conclusions:

  • RNA therapeutics represent a promising frontier in cancer treatment.
  • Success in RNA-based cancer therapy hinges on strategic target identification and advanced delivery systems.
Keywords:
Cancer therapyDeliveryOligonucleotide drugsTargetmRNA vaccines

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