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Issues And Trends In Healthcare Delivery System01:29

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Medicine shortages: impact behind numbers.

Doerine J Postma1,2, Kim Notenboom3, Peter A G M De Smet4

  • 1Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.

Journal of Pharmaceutical Policy and Practice
|March 15, 2023
PubMed
Summary

Medicine shortages significantly impact patients through disease and cost factors. This study developed a framework to assess these economic, clinical, and humanistic outcomes, revealing widespread effects.

Keywords:
ECHO modelFrameworkImpactMedicine shortagesPatient outcomes

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Area of Science:

  • Pharmacoeconomics
  • Health Services Research
  • Patient Outcomes

Background:

  • Limited research exists on the comprehensive impact of medicine shortages on patients.
  • Existing studies often focus on prevalence and product characteristics, neglecting broader consequences.

Purpose of the Study:

  • To assess the overall impact of medicine shortages on economic, clinical, and humanistic outcomes for patients.
  • To develop and apply a framework for evaluating the multifaceted effects of drug unavailability.

Main Methods:

  • A cohort of medicine shortages in the Netherlands (2012-2015) was analyzed.
  • A representative sample of shortages was rated on five impact elements: alternative availability, disease, patient susceptibility, costs, and patient numbers.
  • Impact ratings were converted into numerical scores to determine an overall impact score.

Main Results:

  • Disease (29%) and costs (20%) were most frequently rated as high-impact elements.
  • Nearly half of shortages (47%) had a high impact on at least one element; 10% impacted multiple elements.
  • High impact scores were not significantly linked to specific product characteristics.

Conclusions:

  • A framework assessing economic, clinical, and humanistic outcomes effectively evaluates medicine shortages' impact.
  • All three outcome categories—economic, clinical, and humanistic—contribute to the overall patient impact of medicine shortages.