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Updated: Aug 6, 2025
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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
Published on: December 8, 2023
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Allogeneic stem cell transplantation in adults 2015-21
Camilla Dao Vo1, Anders Eivind Myhre1, Ingerid Weum Abrahamsen1
1Avdeling for blodsykdommer, Oslo universitetssykehus.
Summary
Allogeneic stem cell transplantation outcomes improved significantly from 2015-2021. Survival rates increased, and complications like GVHD decreased, indicating safer and more effective treatments for hematological diseases.
Area of Science:
- Hematology
- Transplantation Medicine
- Oncology
Background:
- Allogeneic stem cell transplantation offers curative potential for hematological malignancies and non-malignant diseases.
- The procedure carries significant risks of treatment-related complications.
- Recent years have seen advancements aimed at mitigating these risks.
Purpose of the Study:
- To retrospectively review quality indicators for allogeneic stem cell transplantation.
- To evaluate changes and outcomes in patients undergoing transplantation between 2015 and 2021.
- To assess the impact of recent modifications on transplantation safety and efficacy.
Main Methods:
- Retrospective analysis of 589 adult patients undergoing first-time allogeneic stem cell transplantation.
- Study conducted at Oslo University Hospital from May 2015 to May 2021.
- Comparison of outcomes across three distinct two-year periods using descriptive statistics.
Main Results:
- Annual first-time transplantations increased from 85 to 113.
- One-year survival rates rose from 68% to 82% across the study periods.
- Graft-versus-host disease (GVHD) incidence decreased, and one-year GVHD-free and relapse-free survival improved from 42% to 60%.
Conclusions:
- Allogeneic stem cell transplantation has become safer and more effective.
- Increased transplant volume correlates with improved survival and reduced complications.
- Quality improvements have positively impacted patient outcomes since 2015.
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