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Motor Evoked Potential Amplitude in Motor Behavior-based Transcranial Direct Current Stimulation Studies: A

Jennifer L Ryan1,2, Emily Eng1, Darcy L Fehlings1,2

  • 1Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada.

Journal of Motor Behavior
|March 15, 2023
PubMed
Summary

Motor evoked potential amplitude (MEPamp) measurements in transcranial direct current stimulation (tDCS) studies targeting the motor cortex may not accurately reflect motor performance improvements. MEPamp changes did not consistently correlate with behavioral gains in healthy individuals.

Keywords:
healthy volunteersmotor cortexmotor evoked potentialsmotor performancetranscranial direct current stimulation

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Area of Science:

  • Neuroscience
  • Motor Control
  • Neurorehabilitation

Background:

  • Transcranial direct current stimulation (tDCS) is increasingly used to modulate primary motor cortex (M1) activity.
  • Motor evoked potential amplitude (MEPamp) is a common neurophysiological marker in M1-targeted tDCS research.
  • The utility of MEPamp in reflecting neural changes associated with motor behavior improvements requires further examination.

Approach:

  • This systematic review analyzed 22 studies investigating M1-targeted tDCS combined with motor practice or performance evaluation in healthy individuals.
  • The review focused on the role of MEPamp as an indicator of neural plasticity.
  • The association between changes in motor performance and MEPamp was specifically examined.

Key Points:

  • Anodal tDCS coupled with motor practice often led to increased MEPamp.
  • However, observed changes in MEPamp did not consistently align with improvements in motor performance.
  • This suggests MEPamp may not be a reliable sole indicator of functional neural changes.

Conclusions:

  • Motor evoked potential amplitude (MEPamp) may not be the most sensitive or appropriate marker for assessing neural changes related to motor performance enhancement in M1-targeted tDCS studies.
  • Future research should consider complementary or alternative neurophysiological and behavioral measures to better understand tDCS effects on motor function.
  • Careful interpretation of MEPamp is warranted when evaluating the efficacy of tDCS interventions aimed at motor skill acquisition or rehabilitation.