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Updated: Aug 6, 2025

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Emerging issues in probiotic safety: 2023 perspectives.

Daniel Merenstein¹, Bruno Pot², Gregory Leyer³

¹Department of Family Medicine, Georgetown University Medical Center, Washington, DC USA.

|March 15, 2023

Summary

This summary is machine-generated.

New guidelines address safe probiotic use, especially for vulnerable groups. Whole genome sequencing is key for identifying risks and ensuring product quality for effective probiotic applications.

Keywords:

ISAPP International Scientific Association for Probiotics and Prebiotics Probiotic antibiotic resistance genome sequencing live biotherapeutic products microbiome microbiota next-generation probiotics safety

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Last Updated: Aug 6, 2025

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Published on: September 10, 2016

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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

Area of Science:

Microbiology
Gastroenterology
Food Science

Background:

Probiotics are widely used by healthy individuals and in clinical settings.
Potential adverse events associated with probiotic consumption are known.
Expanding use into vulnerable populations necessitates updated safety guidelines.

Purpose of the Study:

To develop evidence-based recommendations for the safe and effective use of probiotics.
To address potential acute and long-term risks of probiotic consumption.
To guide the scientific and medical community on assessing probiotic safety.

Main Methods:

Convened a meeting of the International Scientific Association for Probiotics and Prebiotics (ISAPP).
Discussed evidence on risks, vulnerable populations, product quality, and adverse event reporting.
Emphasized the role of whole genome sequencing for strain identification and risk assessment.

Main Results:

Recommendations focus on potential risks, specific needs of vulnerable populations, and product quality.
Whole genome sequencing is highlighted for determining virulence, toxin, and antibiotic resistance genes.
Clear species and strain identification is crucial for safety.

Conclusions:

Actionable recommendations are needed for safe and effective probiotic use, particularly in vulnerable populations.
Probiotic product quality must align with the needs of specific populations.
Robust adverse event reporting systems are essential for monitoring probiotic safety.