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Fe and C additions decrease the dissolution rate of silicon nitride coatings and are compatible with microglial

Estefanía Echeverri1, Charlotte Skjöldebrand1, Paul O'Callaghan2

  • 1Division of Biomedical Engineering, Department of Materials Science and Engineering, Uppsala University, Sweden. cecilia.persson@angstrom.uu.se.

Biomaterials Science
|March 15, 2023
PubMed
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Adding iron and carbon to silicon nitride coatings for metallic implants reduces ion release and maintains cell viability. This suggests potential for enhanced implant longevity and function.

Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Orthopedic Implants

Background:

  • Silicon nitride (SiN) coatings on metallic implants aim to minimize metal ion release.
  • SiN coatings dissolve over time, potentially limiting implant lifespan.
  • Iron (Fe) and carbon (C) additives can modify SiN mechanical properties, but their effect on dissolution and ion release is unknown.

Purpose of the Study:

  • To investigate the impact of Fe and C on SiN coating dissolution rates.
  • To assess the ability of Fe- and C-containing SiN coatings to reduce metal ion release from CoCrMo substrates.
  • To evaluate the biocompatibility of these modified SiN coatings with central nervous system (CNS) microglia.

Main Methods:

  • Compositional gradients of Si, Fe, and C were deposited onto CoCrMo discs using physical vapor deposition.

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  • Surface roughness, ion release (Si, Fe, Co), and microglial viability were assessed.
  • Extracts from coatings were tested on 2D and 3D microglial cultures.

    • Main Results:

    • Fe and C addition did not alter surface roughness or Si/Fe/Co ion release from the substrate.
    • Fe- and C-containing SiN coatings exhibited reduced ion release compared to pure SiN.
    • Coating extracts were compatible with microglial viability in both 2D and 3D models.

    Conclusions:

    • Fe and C additives decrease SiN dissolution rates, potentially by forming stabilizing Si-C or Fe-C bonds.
    • These modified SiN coatings do not compromise microglial viability.
    • Further research is warranted to explore the use of Fe- and C-modified SiN coatings for improved metallic implant performance and longevity.