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Depression in multiple sclerosis.

S L Minden1, J Orav, P Reich

  • 1Division of Psychiatry, Brigham and Women's Hospital, Harvard Medical School.

General Hospital Psychiatry
|November 1, 1987
PubMed
Summary
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Major depression is common in multiple sclerosis (MS) patients, increasing after symptom onset. Depression symptoms can mimic MS, leading to misdiagnosis and undertreatment.

Area of Science:

  • Neurology
  • Psychiatry
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Depression is a common comorbidity in neurological disorders.
  • The relationship between MS onset and major depression requires further investigation.

Purpose of the Study:

  • To determine the prevalence of major depression in multiple sclerosis patients.
  • To explore the temporal relationship between MS onset and major depression.
  • To identify factors associated with major depression in MS.

Main Methods:

  • Utilized standardized interview techniques, diagnostic criteria, and rating scales.
  • Assessed 50 patients with moderately disabled multiple sclerosis.
  • Compared depression rates in MS patients to other medical patient populations.

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Main Results:

  • 54% of MS patients met lifetime criteria for major depression.
  • A significant increase in depression rates was observed after MS symptom onset.
  • MS patients exhibited higher depression rates than other medical patients.
  • Major depression was linked to steroid-treated exacerbations and prior depression history.

Conclusions:

  • Major depression is highly prevalent in multiple sclerosis patients.
  • Depression onset or worsening is associated with MS.
  • Depressive symptoms may be misdiagnosed as MS symptoms, impacting treatment.
  • Early diagnosis and treatment of depression in MS are crucial.