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Related Concept Videos

Cell Migration01:09

Cell Migration

17.1K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
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Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.3K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
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Related Experiment Video

Updated: Aug 6, 2025

A Quantitative Evaluation of Cell Migration by the Phagokinetic Track Motility Assay
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A Quantitative Evaluation of Cell Migration by the Phagokinetic Track Motility Assay

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Peptide modulators of cell migration: Overview, applications and future development.

Jasmin Gattringer1, Christian W Gruber1, Roland Hellinger1

  • 1Medical University of Vienna, Center for Physiology and Pharmacology, Schwarzspanierstrasse 17, A-1090 Vienna, Austria.

Drug Discovery Today
|March 15, 2023
PubMed
Summary

Researchers reviewed over 470 peptides that modulate cell migration, finding most are in early development. Chemical strategies can improve these peptides for therapeutic use in cancer and inflammatory diseases.

Keywords:
cell migrationcyclotidemolecular graftingnature-derived peptidespeptide therapeuticsstabilized peptide scaffolds

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Cell Biology

Background:

  • Cell migration is crucial for organism development and health.
  • Dysregulated cell migration is linked to cancer and inflammatory diseases.
  • Peptides offer therapeutic potential due to their unique properties.

Purpose of the Study:

  • To review and analyze peptides that modulate cell migration.
  • To identify challenges in peptide drug development.
  • To summarize strategies for enhancing peptide drug-like properties.

Main Methods:

  • Literature search for peptides modulating cell migration.
  • Analysis of peptide characteristics and developmental stage.
  • Review of chemical strategies for peptide optimization.

Main Results:

  • Over 470 peptides modulating cell migration were identified.
  • More than 95% of these peptides are in discovery or preclinical stages.
  • A bottleneck exists in transitioning peptide hits to drug leads.

Conclusions:

  • Peptides modulating cell migration represent a promising therapeutic avenue.
  • Early-stage development is a common characteristic of these peptides.
  • Chemical modification strategies are essential for advancing peptide therapeutics.