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Related Concept Videos

Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Fixation and Sectioning01:03

Fixation and Sectioning

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Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
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Related Experiment Video

Updated: Aug 6, 2025

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
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Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

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Update on nail unit histopathology.

Rama Godse1, Olaf Rodriguez1, Katherine Omueti Ayoade1

  • 1Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Human Pathology
|March 15, 2023
PubMed
Summary
This summary is machine-generated.

Histopathologic evaluation of nail unit disorders is crucial. This review covers recent advances in diagnosing conditions like melanoma and onychomycosis, including noninvasive nail clipping analysis.

Keywords:
Inflammatory nail conditionsNail clippingNail disordersNail pathologyNail tumorsNail unitNail unit histopathology

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Area of Science:

  • Dermatopathology
  • Oncology
  • Dermatology

Background:

  • Histopathologic examination of the nail unit is fundamental for diagnosing various nail disorders.
  • Accurate diagnosis relies on understanding characteristic histopathological features of diverse nail conditions.

Purpose of the Study:

  • To review recent advancements in nail unit histopathology.
  • To discuss the literature on diagnosing a spectrum of nail disorders.
  • To highlight the utility of nail clipping histopathology.

Main Methods:

  • Comprehensive literature review of recent publications on nail unit histopathology.
  • Analysis of studies detailing histopathological findings in specific nail diseases.
  • Evaluation of research on nail clipping as a diagnostic method.

Main Results:

  • Recent literature provides updated insights into the histopathology of nail unit lesions.
  • Key diagnostic features for melanoma, squamous cell carcinoma, onychomatricoma, onychopapilloma, onychomycosis, lichen planus, and inflammatory conditions are discussed.
  • Nail clipping histopathology is confirmed as a valuable, noninvasive diagnostic tool.

Conclusions:

  • Histopathology remains essential for accurate nail unit disorder diagnosis.
  • Ongoing research continues to refine diagnostic criteria and techniques.
  • The increasing importance of nail clipping histopathology benefits dermatologists and dermatopathologists.