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Using Time Trade-Off Values to Estimate EQ-5D-Y Value Sets: An Exploratory Study.

Zhihao Yang1, Jie Jiang2, Pei Wang3

  • 1Health Services Management Department, Guizhou Medical University, Gui'an, China; College of Pharmacy, Jinan University, Guangzhou, China.

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PubMed
Summary

The composite time trade-off (cTTO) method is feasible for valuing children's health using the EQ-5D-Y-3L instrument. This study demonstrates its viability for generating value sets in future research.

Keywords:
EQ-5D-Y-3Lcomposite time trade-offfeasibilityvalue set

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Area of Science:

  • Health Economics
  • Psychometrics
  • Patient-Reported Outcomes

Background:

  • The international EQ-5D-Y-3L valuation protocol advises against using the composite time trade-off (cTTO) method due to concerns about high values and feasibility in pediatric populations.
  • Existing valuation methods for the EQ-5D-Y-3L may not fully capture the nuances of children's health states.

Purpose of the Study:

  • To investigate the feasibility of utilizing composite time trade-off (cTTO) data exclusively for the estimation of EQ-5D-Y-3L value sets.
  • To address the limitations of the current EQ-5D-Y-3L valuation protocol regarding the cTTO method.

Main Methods:

  • Analysis of composite time trade-off (cTTO) data from a Chinese EQ-5D-Y-3L valuation study involving 28 health states.
  • Assessment of task feasibility, including survey completion time, participant-reported difficulty, and decision-making challenges.
  • Examination of data distribution and modeling using various statistical approaches, including a random-effects model.

Main Results:

  • 418 participants completed the cTTO interviews, averaging 35.70 minutes.
  • A majority of participants found the tasks easy to understand (74.16%) and differentiate health states (59.33%), with a minority finding decision-making difficult (11.48%).
  • A random-effects model demonstrated optimal performance regarding coefficient significance, monotonicity, and predictive accuracy for the data.

Conclusions:

  • The findings suggest that composite time trade-off (cTTO) data alone is a feasible method for estimating EQ-5D-Y-3L value sets.
  • This approach can be considered a viable option for future EQ-5D-Y-3L valuation studies, potentially improving the assessment of children's health.