Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined continuous theta burst transcranial ultrasound and magnetic stimulation for induction of cortical plasticity.

NeuroImage·2026
Same author

Determining hemispheric language dominance from MEG beta-power modulations: Concordance with fMRI.

NeuroImage·2026
Same author

Frontal Delta Decreasing and Occipital Ictal Alpha Increasing Associated With Migraine in Preictal and Ictal Phases.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

Genome-wide association and population-tailored polygenic risk for Parkinson's disease in Taiwan.

NPJ Parkinson's disease·2026
Same author

Transcranial ultrasound stimulation of motor networks in Parkinson's disease informed by local field potential dynamics.

Science translational medicine·2026
Same author

Parkinson's through a cultural lens: Diversity in disease expression and care.

Journal of Parkinson's disease·2026

Related Experiment Video

Updated: Aug 6, 2025

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality
08:09

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

Published on: September 3, 2015

11.0K

Modulating motor cortical oscillation with coordinated reset multifocal transcranial magnetic stimulation.

Kai-Hsiang Stanley Chen1, Tzu-Kang Hung2,3, Rupesh Kumar Chikara4,5

  • 1Department of Neurology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan.

Journal of Neurophysiology
|March 15, 2023
PubMed
Summary

Coordinated multifocal burst stimulation (COMBS) using three rTMS devices may enhance alpha and beta brainwave activity during motor tasks. This novel neuromodulation technique shows potential for altering motor cortical oscillations without affecting overall cortical excitability.

Keywords:
coordinated resetevent-related desynchronizationlow beta oscillationmotor cortical excitabilityrepetitive transcranial magnetic stimulation (rTMS)

More Related Videos

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation
08:50

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

Published on: August 20, 2019

14.4K
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

9.3K

Related Experiment Videos

Last Updated: Aug 6, 2025

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality
08:09

Multifunctional Setup for Studying Human Motor Control Using Transcranial Magnetic Stimulation, Electromyography, Motion Capture, and Virtual Reality

Published on: September 3, 2015

11.0K
Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation
08:50

Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation

Published on: August 20, 2019

14.4K
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

9.3K

Area of Science:

  • Neuroscience
  • Neuromodulation
  • Motor Control

Background:

  • The theory of coordinated reset (CR) stimulation suggests that multifocal, randomly ordered bursts can reduce oscillatory power in neural generators.
  • Noninvasive neuromodulation techniques offer potential for modulating brain activity and improving motor function.

Purpose of the Study:

  • To develop and evaluate a noninvasive coordinated multifocal burst stimulation (COMBS) system based on CR theory.
  • To investigate the effects of COMBS on motor cortical excitability and oscillatory power during a finger-tapping task in healthy participants.

Main Methods:

  • Developed a COMBS system using three synchronized repetitive transcranial magnetic stimulation (rTMS) devices.
  • Recorded electroencephalography (EEG) and electromyography (EMG) in 16 healthy participants during a finger-tapping task before and after COMBS intervention.
  • Assessed cortical excitability using measures like resting motor threshold, short-interval intracortical inhibition/facilitation, and cortical silent period in a separate group of 14 participants.

Main Results:

  • COMBS did not alter resting oscillatory power at the targeted frequency.
  • Significant increases in α-band power were observed during both preparation and movement stages of the finger-tapping task.
  • Low β-band power increased during the movement stage, and low β-band event-related desynchronization was reduced.
  • No significant changes in reaction time were found, but a trend towards a reduced error rate was observed.
  • No significant changes in cortical excitability measures were detected after COMBS.

Conclusions:

  • COMBS, a novel application of CR theory with multi-rTMS, can modulate cortical oscillatory power, particularly in the α and low β bands, during specific stages of motor tasks.
  • While COMBS did not alter overall cortical excitability, its effects on specific oscillatory bands suggest potential for refining motor control.
  • This study provides initial evidence for CR stimulation's capacity to modify motor cortical oscillations in a targeted manner.