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Related Concept Videos

Regulation of Stroke Volume01:27

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
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Related Experiment Video

Updated: Aug 6, 2025

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
05:40

AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

Published on: November 29, 2024

543

Neuroendocrine regulation in stroke.

Aishika Datta1, Chandrima Saha1, Pratiksha Godse1

  • 1Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat-382355, India.

Trends in Endocrinology and Metabolism: TEM
|March 15, 2023
PubMed
Summary

Stroke disrupts the neuroendocrine system, impacting hormone balance and worsening outcomes. Understanding these neurohormonal links is key to improving stroke prognosis and developing new therapies.

Keywords:
hormone receptorshormoneshypothalamusneuroendocrine systempituitarystroke

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Area of Science:

  • Neuroendocrinology
  • Neurology
  • Endocrinology

Background:

  • The neuroendocrine system integrates the nervous and endocrine systems to regulate hormone secretion.
  • Stroke frequently causes neuroendocrine dysregulation, affecting hormone levels and receptor expression.
  • The hypothalamus-pituitary-thyroid (HPT) and hypothalamus-pituitary-adrenal (HPA) axes are particularly vulnerable post-stroke, influencing outcomes.

Purpose of the Study:

  • To review the role of neurohormonal inter-relationships in stroke regulation, outcomes, and prognosis.
  • To explore the biology of stroke-associated hormones and their regulatory mechanisms.
  • To identify potential therapeutic targets within neuroendocrine pathways for stroke management.

Main Methods:

  • Literature review of studies on neuroendocrine system function after stroke.
  • Analysis of hormonal dysregulation in the context of stroke pathophysiology.
  • Examination of the link between neuroendocrine alterations and post-stroke complications.

Main Results:

  • Neuroendocrine system dysregulation, particularly of the HPT and HPA axes, is common after stroke.
  • Altered hormone secretion and receptor expression contribute to stroke severity and complications like cognitive impairment and depression.
  • Neuroendocrine activity significantly influences stroke vulnerability, susceptibility, and overall prognosis.

Conclusions:

  • The neuroendocrine system plays a critical role in stroke pathophysiology and outcomes.
  • Targeting neuroendocrine pathways offers promising therapeutic strategies for stroke.
  • Further research into neurohormonal regulation is essential for advancing stroke care.