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Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
Basma Mohamed1, Keerthi Yarlagadda1, Zachary Self1
1Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Translational Stroke Research
|March 16, 2023
Summary
Sleep-disordered breathing (SDB) increases stroke risk and impacts outcomes. Treating obstructive sleep apnea (OSA) is crucial for managing stroke patients and improving their prognosis.
Area of Science:
- Neurology
- Sleep Medicine
- Cardiovascular Science
Background:
- Sleep-disordered breathing (SDB) is a consequence of stroke, affecting respiratory centers.
- Obstructive sleep apnea (OSA) elevates stroke risk via local and systemic pathways.
- OSA's impact on stroke outcomes is underemphasized in clinical guidelines.
Purpose of the Study:
- To investigate the correlation between OSA and stroke, including pathophysiology.
- To highlight the significance of OSA treatment in stroke management.
- To inform clinical prediction of stroke outcomes based on pre-existing OSA.
Main Methods:
- Scoping review methodology.
- Analysis of inter-relational pathophysiology between OSA and stroke.
- Literature synthesis on OSA treatment and stroke outcomes.
Main Results:
- Established link between OSA and increased stroke risk.
- Identified systemic effects of OSA contributing to stroke.
- Underscored the need for greater attention to OSA in stroke care.
Conclusions:
- Understanding OSA-stroke pathophysiology is vital for acute ischemic stroke management.
- OSA treatment can positively influence stroke outcomes.
- Pre-existing OSA is a factor in predicting stroke patient prognosis.
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