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Updated: Aug 6, 2025
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Isolation of Adipose Tissue Nuclei for Single-Cell Genomic Applications
Published on: June 12, 2020
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An integrated single cell and spatial transcriptomic map of human white adipose tissue
Lucas Massier1, Jutta Jalkanen1, Merve Elmastas1
1Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 83, Huddinge, Sweden.
Nature Communications
|March 16, 2023
Summary
This study created a detailed map of human white adipose tissue (WAT) cells by analyzing multiple datasets. The findings reveal connections between specific cell types and metabolic health conditions like insulin resistance.
Area of Science:
- Metabolomics
- Cell Biology
- Genomics
Background:
- Human white adipose tissue (WAT) single-cell studies lack consensus nomenclature and rely on small cohorts.
- Understanding WAT cellular heterogeneity is crucial for metabolic research.
Conclusions:
- The developed meta-map serves as a valuable resource for human WAT cellular and microarchitectural landscape.
- Provides insights into the associations between specific cell types and metabolic health.
