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Standardized growth charts for children with osteogenesis imperfecta

Marie-Eve Robinson1,2, Damian Rauch3, Francis H Glorieux3

  • 1Shriners Hospital for Children - Canada, McGill University, Montreal, QC, Canada. mrobinson@cheo.on.ca.

Pediatric Research
|March 16, 2023
PubMed

Insights

New growth charts for Osteogenesis Imperfecta (OI) provide type- and sex-specific height data for children. These charts help track growth from infancy to adulthood, addressing a critical gap in OI care.

Area of Science:

  • Pediatric endocrinology
  • Skeletal dysplasias
  • Medical genetics

Background:

  • Osteogenesis Imperfecta (OI) is characterized by short stature, varying by type (mild, moderate, severe).
  • Existing pediatric growth charts lack specificity for OI types and sex.
  • There is a need for standardized growth assessment tools for individuals with OI.

Purpose of the Study:

  • To develop standardized, type- and sex-specific growth charts for Osteogenesis Imperfecta (OI) across all pediatric ages.
  • To provide clinicians with tools for monitoring growth in children with OI.
  • To generate height multiplier curves for predicting adult height in OI patients.

Main Methods:

  • Collected height data from 573 individuals with OI (types I, III, IV) aged 3 months to 20 years (6523 observations).
  • Generated OI type- and sex-specific growth charts for infants and children/adolescents using the LMS method.
  • Smoothed percentile curves for accurate growth assessment.

Main Results:

  • Age-related decline in height z-scores was observed across all OI types, more pronounced in females.
  • Developed type- and sex-specific growth charts for OI from infancy through adolescence.
  • Created height multiplier curves to predict adult height for children with OI.

Conclusions:

  • The newly developed standardized growth charts enable comprehensive growth assessment for individuals with OI from infancy to adulthood.
  • These charts address a significant unmet need in the clinical management of Osteogenesis Imperfecta.
  • The study provides the first set of OI-specific growth charts for pediatric populations.
Abstract

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