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Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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Histone lysine methyltransferase-related neurodevelopmental disorders: current knowledge and saRNA future therapies

Charlotte Roth1, Helena Kilpinen2,3, Manju A Kurian1,4

  • 1Molecular Neurosciences, Developmental Neurosciences Programme, Zayed Centre for Research into Rare Disease in Children, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

Frontiers in Cell and Developmental Biology
|March 16, 2023
PubMed
Summary

Histone lysine methyltransferases are crucial for brain development. Mutations cause neurodevelopmental disorders, and understanding their role may lead to new RNA-based therapies for these conditions.

Keywords:
brain organoidsepigenetics (chromatin remodeling)histone lysine methyltransferases (HKMTs)neurodevelopmental disorders (NDDs)small-activating RNA (saRNA)

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