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Weight loss in hypertrophic cardiomyopathy: A clinical case series

Maria C Reuter1, Daniele Massera1, Leon Axel2

  • 1Hypertrophic Cardiomyopathy Program, The Leon H. Charney Division of Cardiology, NYU Langone Health, New York, NY, USA.

International Journal of Cardiology. Cardiovascular Risk and Prevention
|March 16, 2023
PubMed

Insights

Weight loss in hypertrophic cardiomyopathy (HCM) patients can decrease left ventricular (LV) mass and wall thickness. This may improve cardiac function and symptoms in obese individuals with HCM.

Area of Science:

  • Cardiology
  • Obesity Medicine
  • Medical Imaging

Background:

  • Obesity is common in hypertrophic cardiomyopathy (HCM) patients.
  • Obese HCM patients exhibit increased wall thickness, left ventricular (LV) mass, and impaired hemodynamic function.
  • Weight reduction may positively impact the HCM phenotype.

Observation:

  • Six HCM patients underwent weight loss via lifestyle changes or bariatric surgery.
  • Cardiac MRI or CT scans were obtained before and after weight loss.
  • Evaluated changes in LV mass, indexed LV mass, and LV segment wall thickness.

Findings:

  • A mean reduction in LV mass and indexed LV mass was observed.
  • A numerical decrease in mean wall thickness was noted in most LV segments.
  • Patients experienced a reduction in New York Heart Association (NYHA) class symptoms.

Implications:

  • Substantial weight loss in HCM patients can lead to decreased LV mass and wall thickness.
  • Weight loss may promote favorable cardiac remodeling in HCM.
  • Further prospective studies are warranted to confirm the benefits of weight loss in HCM.
Abstract

Keywords:
CardiomyopathyCase reportObesityWeight loss

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