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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Cell therapy for neuropathic pain.

QingHua Yin1,2, TianHao Zou1,2, ShuJun Sun1,2

  • 1Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Molecular Neuroscience
|March 16, 2023
PubMed
Summary
This summary is machine-generated.

Cell therapy shows promise for treating neuropathic pain (NP) by addressing underlying causes, unlike current treatments that offer limited relief. This review explores cell graft advancements for NP stemming from nerve injury.

Keywords:
analgesiacell therapynerve injuryneuropathic painstem celltransplantation

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Pain Management

Background:

  • Neuropathic pain (NP) arises from somatosensory system damage, involving complex molecular pathways like sensitization.
  • Existing treatments for NP are often ineffective, with over 50% of patients experiencing inadequate pain relief.
  • Current therapies focus on symptom management rather than addressing the root pathophysiology of NP.

Purpose of the Study:

  • To review the application of cell grafts as a therapeutic strategy for neuropathic pain (NP).
  • To synthesize recent advancements and potential adverse effects of cell transplantation in NP treatment.
  • To elucidate the underlying mechanisms of cell therapy for NP to guide clinical practice.

Main Methods:

  • Literature review of pre-clinical and clinical studies on cell transplantation for NP.
  • Synthesis of data on efficacy, safety, and mechanisms of action of cell grafts in NP.
  • Analysis of current research trends and challenges in cell-based NP therapy.

Main Results:

  • Cell transplantation-based therapies have demonstrated encouraging outcomes in pre-clinical and clinical studies for NP.
  • Cell grafts offer a potential approach to target the underlying pathophysiology of NP.
  • The review consolidates current knowledge on advances and adverse effects of cell therapy for NP.

Conclusions:

  • Cell therapy represents a promising alternative for treating neuropathic pain (NP) by addressing its core mechanisms.
  • Further research and clinical translation are needed to optimize cell transplant-based therapies for NP.
  • This review provides valuable insights for clinicians and researchers developing novel NP treatments.