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Pediatric Cerebral Cavernous Malformation: A Single-Centered Experience of 23 Cases
Yavuz Aras1, Ilyas Dolas, Duygu Dolen
1Istanbul University, Istanbul Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey.
Turkish Neurosurgery
|March 16, 2023
Summary
Pediatric cavernous malformations (CMs) are aggressive and require early surgical intervention. Microsurgical total resection, including hemosiderin-stained tissue, offers the best long-term outcomes for these challenging brain lesions.
Area of Science:
- Neurology
- Neurosurgery
- Pediatric Medicine
Background:
- Pediatric cavernous malformations (CMs) present unique challenges compared to adult cases.
- Understanding their clinical and radiological characteristics is crucial for effective management.
Purpose of the Study:
- To describe the clinical and radiological features of pediatric CMs.
- To evaluate surgical approaches and outcomes in a single center.
Main Methods:
- Retrospective review of pediatric patients with CMs treated between 2010 and 2020.
- Analysis of radiological, clinical, demographic, and treatment data.
Main Results:
- 23 pediatric patients analyzed; common symptoms included headaches and seizures.
- Most lesions were single (20/23), with varying Zabramski classifications.
- Seven patients had coexisting deep venous anomalies; 21 underwent microsurgical resection with complete resection and no major complications.
Conclusions:
- Pediatric CMs are more aggressive and should not be underestimated.
- Microsurgical total resection is the preferred treatment, especially with resection of perilesional hemosiderin.
- Early surgical intervention yields favorable long-term results, including seizure control.
