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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Updated: Aug 6, 2025

Zebrafish Keratocyte Explants to Study Collective Cell Migration and Reepithelialization in Cutaneous Wound Healing
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Acellular fish skin for wound healing.

Ali Esmaeili1, Esmaeil Biazar2, Maryam Ebrahimi3

  • 1Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

International Wound Journal
|March 16, 2023
PubMed
Summary

Fish skin offers a cost-effective, safe alternative for wound healing grafts. Optimized decellularization preserves its structure, enhancing its potential as a tissue-engineered skin substitute.

Keywords:
biological and physical & mechanical propertiesdecellularizationfish skinin-vivo studieswound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Fish skin is emerging as a promising biomaterial for skin grafting.
  • Its use offers advantages like reduced disease transmission and lower production costs.
  • Effective decellularization is crucial for preserving fish skin's structural integrity.

Purpose of the Study:

  • To review decellularization techniques for fish skin.
  • To investigate the biological, physical, and mechanical properties of fish skin scaffolds.
  • To explore therapeutic applications of fish skin in wound healing.

Main Methods:

  • Literature review of studies on fish skin decellularization.
  • Analysis of biological, physical, and mechanical properties of decellularized fish skin.
  • Examination of clinical and preclinical wound healing applications.

Main Results:

  • Various decellularization methods can yield 3D acellular scaffolds from fish skin.
  • These scaffolds retain key extracellular matrix components and structural morphology.
  • Fish skin grafts demonstrate potential for accelerating wound healing.

Conclusions:

  • Decellularized fish skin is a viable alternative to traditional skin grafts.
  • Optimized decellularization processes are key to successful skin regeneration.
  • Fish skin holds significant therapeutic potential for wound management.