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Related Concept Videos

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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[Primary renal marginal zone B lymphoma].

Amine Benmoussa1, I Moukrim1, N Khoubila1

  • 1Service d'Hématologie clinique et d'Oncologie pédiatrique, Faculté de Médecine et de Pharmacie Hassan II Casablanca, CHU 20 Août, Casablance, Maroc.

Revue Medicale De Liege
|March 16, 2023
PubMed
Summary
This summary is machine-generated.

Primary renal marginal zone B lymphoma, a rare condition, can cause kidney failure. Treatment with rituximab and chemotherapy showed a positive outcome in a recent case.

Keywords:
ImmunochemotherapyKidney FailureMALT marginal zone B lymphoma

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Area of Science:

  • Oncology
  • Nephrology
  • Hematology

Background:

  • Primary renal marginal zone B lymphoma is an exceptionally rare malignancy.
  • Renal involvement by lymphoma typically indicates disseminated disease rather than primary organ involvement.

Observation:

  • A 53-year-old patient presented with lower back pain and acute kidney injury.
  • Renal biopsy confirmed extranodal marginal zone B-cell lymphoma of MALT type.
  • Positron emission tomography (PET) scan revealed bilateral renal infiltration.

Findings:

  • The patient received a treatment regimen combining rituximab with chemotherapy (cyclophosphamide, prednisone, and oncovin).
  • The therapeutic intervention resulted in a favorable clinical outcome.

Implications:

  • This case highlights the possibility of primary renal marginal zone B-cell lymphoma.
  • Effective treatment strategies involving immunotherapy and chemotherapy can be employed for this rare entity.
  • Further research into primary renal lymphomas is warranted to improve diagnostic and therapeutic approaches.