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Updated: Aug 6, 2025

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
Effect of microbiology comment nudging on antibiotic use in asymptomatic bacteriuria: A before-and-after
Madeline G Belk1, Olivia D Hammond2, Callie C Seales3
1Huntsville Hospital, Department of Pharmacy, Huntsville, Alabama.
Objective:
To describe the effect of a microbiology comment nudge on antibiotic use for asymptomatic bacteriuria (ASB).
Design:
Single-center, before-and-after, quasi-experimental study.
Setting:
Community-based, public, not-for-profit teaching hospital in the southeastern United States.
Participants:
Adult inpatients with a positive urine culture and the absence of urinary tract infection signs and symptoms.
Intervention:
Implementation of a microbiology comment nudge on urine cultures.
Results:
In total, 204 patients were included in the study. Antibiotics were less likely to be continued beyond 72 hours in the postimplementation group: 57 (55%) of 104 versus 38 (38%) of 100 (P = .016). They were less likely to have antibiotics continued beyond 48 hours: 60 (58%) of 104 versus 43 (43%) of 100 (P = .036). They were also less likely to have antibiotics prescribed at discharge 35 (34%) of 104 versus 20 (20%) of 100 (P = .028). In addition, they had fewer total antibiotic days of therapy: 4 (IQR, 1-6) versus 1 (IQR, 0-6) (P = .022).
Conclusion:
Microbiology comment nudging may contribute to less antibiotic utilization in patients with ASB.
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