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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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The relationship between venous insufficiency and serum magnesium level
Serhat Caliskan1, Mehmet Atay2, Seyda Gunay-Polatkan3
1Istanbul Bahcelievler State Hospital, Department of Cardiology
Magnesium Research
|March 16, 2023
Summary
Low serum magnesium levels are linked to chronic venous insufficiency. This study found significantly lower magnesium in patients with venous insufficiency compared to healthy controls, suggesting a potential risk factor.
Area of Science:
- Biochemistry
- Vascular Biology
- Medical Research
Background:
- Magnesium is a crucial intracellular cation involved in numerous enzymatic pathways and vascular smooth muscle cell function.
- Magnesium deficiency is associated with increased inflammation, a key factor in various disease pathogeneses.
- Vascular smooth muscle cell integrity is vital for maintaining circulatory health.
Purpose of the Study:
- To investigate the association between serum magnesium levels and the development of chronic venous insufficiency (CVI).
- To compare serum magnesium levels in individuals with CVI against a healthy control group.
- To explore magnesium's potential role in the pathophysiology of CVI.
Main Methods:
- A comparative study involving 394 patients diagnosed with CVI and 206 healthy controls.
- CVI diagnosis was confirmed via physical examination and color Doppler ultrasonography, defining reflux criteria.
- Serum magnesium levels, inflammatory markers, and clinical parameters were assessed and compared between the CVI and control groups.
Main Results:
- A total of 600 participants (394 CVI patients, 206 controls) were analyzed, with no significant age or gender differences between groups.
- Serum magnesium levels were significantly lower in the CVI group (median 1.90 mg/dL) compared to the control group (median 2.1 mg/dL).
- The observed difference in serum magnesium was statistically significant (p<0.001).
Conclusions:
- Low serum magnesium levels may represent a potential risk factor for developing chronic venous insufficiency.
- The findings suggest a link between magnesium homeostasis and vascular health in the context of CVI.
- Further research is warranted to elucidate the precise mechanisms underlying magnesium's role in CVI pathogenesis.
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