Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of the 1D/2D Dimensionality by Ligand Exchange in a Series of Cu- and Ag-Naphthalenethiolate Coordination Polymers: Effect on Conductivity and Photoemission.

ACS omega·2026
Same author

Golden immunity: gold complexes as emerging triggers of immunogenic cell death.

Chemical science·2026
Same author

Searching for Suitable [Cu(N^N){(PPh<sub>2</sub>)<sub>2</sub>C<sub>2</sub>B<sub>9</sub>H<sub>10</sub>}] Thermally Activated Delayed Fluorescent Dopants: Optimization of the Quantum Yield through the 2-(4-Thiazolyl)benzimidazole Diimine Functionalization.

Inorganic chemistry·2026
Same author

Dual-Action NSAID-Gold(I) Alkynyl Hybrids for Synergistic Anti-Inflammatory and Anticancer Therapy of Colorectal Cancer.

Inorganic chemistry·2026
Same author

On the nature and feasibility of unsupported Au⋯Pd metallophilic interactions: a correlated computational study.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

NIR-Emitting Cyclometalated Cp*-Ir(III) Complexes: Impact of Ligand π-Extension on Aggregation Behavior and Photophysical Properties.

Inorganic chemistry·2026

Related Experiment Video

Updated: Aug 6, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.0K

Silver-Based Terpyridine Complexes as Antitumor Agents.

María Gil-Moles1, M Elena Olmos1, Miguel Monge1

  • 1Departamento de Química, Universidad de La Rioja, Centro de investigación de Síntesis Química (CISQ), Complejo Científico-Tecnológico, 26004-, Logroño, Spain.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 16, 2023
PubMed
Summary
This summary is machine-generated.

New silver complexes show high anticancer activity and selectivity against tumor cells. These compounds interact with DNA and induce apoptosis through a mitochondrial pathway, offering potential therapeutic applications.

Keywords:
cancercytotoxicitypolynuclear compoundssilverterpyridine

More Related Videos

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

57.8K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.6K

Related Experiment Videos

Last Updated: Aug 6, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.0K
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

57.8K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.6K

Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Molecular Biology

Background:

  • Silver complexes with terpyridine or tetra-2-pyridinylpyrazine ligands are underexplored for anticancer properties.
  • Combining silver's properties with DNA-binding ligands offers therapeutic potential.

Purpose of the Study:

  • To synthesize and characterize novel silver complexes.
  • To evaluate their antiproliferative activity, stability, and DNA-binding capabilities.
  • To elucidate their mechanism of cell death induction.

Main Methods:

  • Synthesis and structural characterization of silver complexes.
  • In vitro antiproliferative assays against various tumor cell lines.
  • Cellular stability and cometor-DNA binding studies.
  • Apoptosis induction and mechanism analysis (mitochondrial pathway).

Main Results:

  • High cytotoxicity observed against diverse tumor cells.
  • Significant selectivity index between tumor cells and healthy T lymphocytes for certain compounds.
  • Moderate intercalation into cometor-DNA demonstrated.
  • Induction of apoptosis via a mitochondrial pathway confirmed.

Conclusions:

  • Novel silver complexes exhibit potent and selective anticancer activity.
  • These compounds interact with DNA and trigger apoptosis through mitochondrial pathways.
  • Further investigation is warranted for their development as anticancer agents.