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The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability

Catherine L W Miller1, Fred Winston2

  • 1Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Cell Reports
|March 16, 2023
PubMed
Summary

The histone chaperone Spt6 is crucial for DNA replication and genome stability in yeast. This protein promotes the loading of the MCM helicase at replication origins, independent of its role in transcription.

Keywords:
CP: Molecular biologyDNA replicationchromatingenome stabilityhistone chaperonesspt6

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