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An iterative neural processing sequence orchestrates feeding.

Qingqing Liu1, Xing Yang1, Moxuan Luo2

  • 1Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Center for Excellence in Brain Science and Intelligence Technology, the Brain Cognition and Brain Disease Institute, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Neuron
|March 16, 2023
PubMed
Summary
This summary is machine-generated.

Neural circuits involving agouti-related peptide (AgRP) neurons, lateral hypothalamus (LH), and dorsal raphe (DR) guide feeding behaviors. This study reveals how these brain areas resolve motivational conflicts to optimize goal-directed eating.

Keywords:
AgRP neuronappetitebehavior identificationdorsal rapheeating disorderfeeding initiationfeeding maintenancefood consumptionlateral hypothalamusmotivation competition

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Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Computational Neuroscience

Background:

  • Satiating appetite involves complex neural control, but the specific roles of different neuron populations in orchestrating feeding behaviors and motivations remain unclear.
  • Understanding the neural basis of feeding is crucial for addressing metabolic disorders and appetite regulation.

Purpose of the Study:

  • To investigate the discrete neural populations and their roles in orchestrating distinct behaviors and motivations throughout the feeding process.
  • To elucidate the neural mechanisms underlying the resolution of motivational conflicts during feeding.

Main Methods:

  • Development of a machine-learning-assisted behavior tracking system to delineate the behavioral repertoire of mice during feeding.
  • Analysis of the iterative activation sequences of specific neuronal populations, including agouti-related peptide (AgRP)-expressing neurons in the arcuate (ARC) nucleus, GABAergic neurons in the lateral hypothalamus (LH), and neurons in the dorsal raphe (DR).

Main Results:

  • Feeding behavior is fragmented, with competing motivations for food consumption and environmental exploration.
  • An iterative activation sequence of ARC AgRP neurons, LH GABAergic neurons, and DR neurons orchestrates the preparation, initiation, and maintenance of feeding segments.
  • This neural sequence resolves motivational conflicts, optimizing feeding bouts.

Conclusions:

  • The study identifies a specific neural circuit and activation pattern that governs the complex process of feeding.
  • The findings suggest a generalizable rule for how iterative neural processing resolves motivational conflicts to optimize goal-directed behaviors, applicable beyond feeding.