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MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural
E S Lander1, P Green, J Abrahamson
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
Genomics
|October 1, 1987
Summary
MAPMAKER is a new computer package for genetic linkage mapping. It uses efficient algorithms for multipoint analysis, aiding geneticists in constructing accurate genetic maps for various organisms.
Area of Science:
- Genetics
- Bioinformatics
- Computational Biology
Background:
- Genetic linkage maps are crucial for understanding organismal genetics.
- Restriction Fragment Length Polymorphisms (RFLPs) have enabled the assembly of genetic maps.
- Accurate map construction necessitates multipoint linkage analysis in specific pedigrees.
Purpose of the Study:
- To introduce MAPMAKER, a specialized computer package for genetic linkage map construction.
- To provide geneticists with an efficient tool for multipoint linkage analysis.
- To facilitate the exploration of linkage data through an interactive command language.
Main Methods:
- Development of MAPMAKER, a computer package utilizing an efficient algorithm.
- Implementation of simultaneous multipoint analysis for any number of loci.
- Inclusion of an interactive command language for user-friendly data exploration.
Main Results:
- MAPMAKER enables efficient and simultaneous multipoint linkage analysis.
- The program facilitates the construction of genetic linkage maps.
- MAPMAKER has been successfully applied to map construction in humans and plants.
Conclusions:
- MAPMAKER is a valuable tool for geneticists engaged in constructing genetic linkage maps.
- The software's efficiency and interactive nature streamline the mapping process.
- MAPMAKER supports the development of comprehensive genetic maps across diverse organisms.