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Staged Open Cranial Surgery for Primary Intra-axial Neoplasms: A Systematic Review.

Nicholas Bui¹, Cathleen Kuo², Nolan J Brown²

¹Loma Linda University School of Medicine, Loma Linda, California, USA.

World Neurosurgery

|March 16, 2023

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This summary is machine-generated.

Staged surgery for primary brain tumors is less common than for skull base lesions. This review examines its indications, timing, approaches, and complications in pediatric and adult patients.

Area of Science:

Neurosurgery
Oncology
Systematic Review

Background:

Staged surgery is common for skull base lesions but less reported for primary intra-axial neoplasms.
This systematic review investigates staged surgical procedures for primary intra-axial neoplasms.

Approach:

A systematic literature search was conducted using PRISMA guidelines across PubMed, Web of Science, and Cochrane databases.
Seven articles involving 17 pediatric and 4 adult patients were included for qualitative assessment and data synthesis.

Key Points:

Staged approaches were more frequent in pediatric patients for astrocytoma and glioma resection.
Timing between stages varied: 5-10 days for pediatric vs. 18 days-4 months for adult patients.
Complications differed between age groups, including neurological deficits, hydrocephalus, and respiratory failure.

Keywords:

Astrocytoma Complications Ependymoma Glioma Intra-axial Intracranial Neoplasm Oligodendroglioma Staged Tumor

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Conclusions:

This is the first comprehensive review of staged surgery for primary intra-axial cranial neoplasms.
Complications associated with staged intra-axial surgery show heterogeneity, comparable to single-stage and skull base procedures.