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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
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Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Functional constipation in children: What physicians should know.

Duc Long Tran1,2, Palittiya Sintusek3

  • 1Thailand and Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Bangkok, Thailand.

World Journal of Gastroenterology
|March 17, 2023
PubMed
Summary
This summary is machine-generated.

Functional constipation (FC) affects 14.4% of children globally. While osmotic laxatives are common, adherence and parental concerns hinder treatment, necessitating exploration of novel therapies.

Keywords:
ChildrenConstipationHerbalLaxativeToilet trainingTreatment

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Pharmacology

Background:

  • Functional constipation (FC) is the most prevalent functional gastrointestinal disorder in children, with a global prevalence of 14.4% based on Rome IV criteria.
  • Its multifactorial pathophysiology complicates management, with osmotic laxatives and toilet training being the primary treatments.
  • Treatment failure is often linked to children's medication adherence and parental concerns about long-term laxative use.

Purpose of the Study:

  • To provide a comprehensive overview of functional constipation in children.
  • To review global prevalence, pathogenesis, diagnostic criteria, and management strategies for pediatric FC.
  • To explore both conventional and emerging therapeutic options for functional constipation.

Main Methods:

  • Systematic review of existing literature on pediatric functional constipation.
  • Analysis of diagnostic criteria, including Rome IV criteria.
  • Evaluation of pharmacological and non-pharmacological treatment options, including novel therapies.

Main Results:

  • Osmotic laxatives, alongside toilet training, are the current mainstay treatment for pediatric functional constipation.
  • Novel therapies including probiotics, synbiotics, and specific receptor agonists show promise but require further research.
  • Non-pharmacological approaches like dietary changes and physiotherapy are important, with surgery reserved for refractory cases.

Conclusions:

  • Functional constipation is a common childhood disorder requiring multifaceted management approaches.
  • Adherence and parental concerns are key challenges in current treatment paradigms.
  • Further research into novel therapies and personalized treatment strategies is crucial for improving outcomes in pediatric functional constipation.