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Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Xin Liu1, Lili An2, Yonghui Zhou1

  • 1College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People's Republic of China.

Infection and Drug Resistance
|March 17, 2023
PubMed
Abstract

Insights

Patrinia scabiosaefolia effectively combats methicillin-resistant Staphylococcus epidermidis (MRSE) by damaging its cell wall and membrane. This traditional Chinese medicine also influences the bacteria's beta-lactamase production, energy metabolism, and antioxidant systems.

Area of Science:

  • Microbiology
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Staphylococcus epidermidis is a leading cause of septicemia and exhibits increasing antibiotic resistance.
  • Methicillin-resistant S. epidermidis (MRSE) strains are multi-drug resistant, posing a significant threat to public health.
  • Patrinia scabiosaefolia, a traditional Chinese medicine, demonstrates potent antibacterial activity against MRSE, but its mechanism remains unclear.

Purpose of the Study:

  • To elucidate the mechanism by which Patrinia scabiosaefolia exerts its antibacterial effects against MRSE.
  • To investigate the impact of P. scabiosaefolia on the cellular structures and metabolic pathways of MRSE.

Main Methods:

  • Systematic analysis of MRSE cell wall and cell membrane morphology.
  • Quantification of beta-lactamase and PBP2 production in response to P. scabiosaefolia.
  • Assessment of energy metabolism and antioxidant system activity in MRSE.

Main Results:

  • Patrinia scabiosaefolia was found to significantly damage the cell wall and cell membrane of MRSE.
  • The antibacterial action involves alterations in beta-lactamase production, energy metabolism, and the antioxidant system of MRSE.

Conclusions:

  • Patrinia scabiosaefolia possesses a multi-faceted mechanism against MRSE, involving direct cellular damage and modulation of key bacterial systems.
  • Understanding these mechanisms provides a basis for developing novel strategies to control MRSE infections using P. scabiosaefolia.
Keywords:
Patrinia scabiosifoliaantioxidant systemenergy metabolismmethicillin-resistantStaphylococcus epidermidisβ-lactamase

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