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Related Experiment Video

Updated: Aug 6, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
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Orbital Lymphoma Masquerading as Euthyroid Orbitopathy.

Muhammad Waqar Sharif1, Sai Mungara1, Kelash Bajaj2

  • 1Internal Medicine, Texas Tech University Health Science Center at Permian Basin, Odessa, USA.

Cureus
|March 17, 2023
PubMed
Summary
This summary is machine-generated.

Orbital lymphoma can mimic thyroid eye disease (TED), causing inflammation and proptosis. Differentiating these conditions is crucial, especially in younger patients, to ensure accurate diagnosis and timely treatment.

Keywords:
bilateral proptosiseuthyroid orbitopathymucosa-associated lymphoid tissue (malt) lymphomaprimary orbital lymphomathyroid-associated orbitopathy

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Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Background:

  • Thyroid eye disease (TED), or Graves' orbitopathy (GO), is the most common cause of orbital inflammation, often linked to hyperthyroidism.
  • Distinguishing TED from other orbital inflammatory conditions is essential for appropriate management.

Observation:

  • The case presented atypical features inconsistent with typical TED, including unilateral proptosis, lack of lid changes, and muscle dysfunction.
  • These signs suggested a non-TED mediated orbital process requiring further investigation.

Findings:

  • Orbital lymphoma, specifically mucosa-associated lymphoid tissue (MALT) lymphoma, was diagnosed in a 27-year-old patient.
  • The patient had a history of euthyroid ophthalmopathy, highlighting the importance of considering space-occupying lesions.

Implications:

  • Orbital inflammation necessitates a broad differential diagnosis, including space-occupying lesions like lymphoma.
  • Early suspicion and exclusion of orbital lymphoma are critical, even in young patients presenting with proptosis and restricted eye movements.