Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

632
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
632
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

2.3K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.

Science advances·2025
Same author

Electrical Coordinated Reset stimulation induces network desynchronization in an in vivo model of status epilepticus.

Epilepsy & behavior : E&B·2025
Same author

Editorial: Neuromodulation using spatiotemporally complex patterns.

Frontiers in neuroinformatics·2024
Same author

Synaptic reorganization of synchronized neuronal networks with synaptic weight and structural plasticity.

PLoS computational biology·2024
Same author

Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections.

Frontiers in network physiology·2024
Same author

Simulated dataset on coordinated reset stimulation of homogeneous and inhomogeneous networks of excitatory leaky integrate-and-fire neurons with spike-timing-dependent plasticity.

Data in brief·2024

Related Experiment Video

Updated: Aug 6, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

459

Long-Lasting Desynchronization of Plastic Neuronal Networks by Double-Random Coordinated Reset Stimulation.

Ali Khaledi-Nasab1, Justus A Kromer1, Peter A Tass1

  • 1Department of Neurosurgery, Stanford University, Stanford, CA, United States.

Frontiers in Network Physiology
|March 17, 2023
PubMed
Summary

Randomizing deep brain stimulation parameters like timing and amplitude can enhance long-lasting desynchronization effects for neurological disorders such as Parkinson's disease (PD). Double-random coordinated reset (CR) stimulation shows improved robustness and potential for reduced current.

Keywords:
coordinated reset stimulationlong-lasting desynchronizationplastic neuronal networksrandomized stimulus amplitudesspike-timing-dependent plasticity

More Related Videos

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

11.7K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.4K

Related Experiment Videos

Last Updated: Aug 6, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

459
Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

11.7K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.4K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biomedical Engineering

Background:

  • Neuronal hypersynchrony underlies neurological disorders like Parkinson's disease (PD).
  • High-frequency deep brain stimulation (HF DBS) is a standard treatment for PD, but its effects are temporary.
  • Coordinated reset (CR) stimulation offers a theory-based approach to counteract neuronal synchrony and achieve lasting desynchronization.

Purpose of the Study:

  • To investigate the long-lasting desynchronization effects of CR stimulation with randomized stimulus amplitudes and/or timings.
  • To determine if randomization improves the robustness of CR stimulation against variations in stimulation frequency.
  • To assess the potential of double-random CR stimulation for enhanced therapeutic outcomes in PD.

Main Methods:

  • Computer simulations of leaky integrate-and-fire (LIF) neuron networks with spike-timing-dependent plasticity.
  • Analytical calculations to study CR stimulation with amplitude randomization, timing randomization, or both.
  • Systematic variation of CR stimulation frequency and the number of stimulated neuronal subpopulations.

Main Results:

  • Both amplitude and timing randomization individually improved the robustness of long-lasting desynchronization effects.
  • Double-random CR stimulation (combining amplitude and timing randomization) demonstrated superior long-lasting desynchronization compared to regular CR.
  • Stimulus amplitude randomization potentially reduces overall stimulation current and enhances frequency robustness.

Conclusions:

  • Randomized CR stimulation, particularly double-random CR, offers a promising strategy for robust and potentially more effective long-lasting desynchronization in neurological disorders.
  • This approach may lead to improved therapeutic outcomes in Parkinson's disease by maintaining desynchronization across varying stimulation frequencies.
  • Amplitude randomization presents a novel mechanism for improving frequency robustness and potentially reducing stimulation energy requirements.