Related Experiment Video
Updated: Aug 6, 2025
06:55
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
12.1K
Gastric squamous metaplasia observed by image-enhanced endoscopy.
Eri Iwata1, Mitsushige Sugimoto1, Yoshika Akimoto1
1Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
DEN Open
|March 17, 2023
Summary
A 13-year endoscopic surveillance revealed a growing gastric lesion in a Helicobacter pylori-positive patient. The lesion was identified as benign gastric squamous metaplasia, not malignancy.
Area of Science:
- Gastroenterology
- Endoscopic Imaging
- Pathology
Background:
- A 61-year-old female with Helicobacter pylori infection and gastroesophageal reflux disease underwent annual surveillance endoscopy.
- A 10-mm depressed lesion was noted in the gastric cardia in 2009.
Observation:
- The lesion gradually increased to 15 mm over 13 years.
- Image-enhanced endoscopy techniques (chromoendoscopy, NBI, TCI modes 1 & 2) highlighted the lesion's mucosal characteristics.
- No vascular or structural abnormalities were detected by advanced imaging.
Findings:
- Pathological examination confirmed gastric squamous metaplasia without atypia or malignancy.
- The lesion demonstrated a significant size change over a decade of observation.
Implications:
- This case highlights the importance of long-term endoscopic surveillance for gastric lesions.
- Advanced endoscopic imaging can aid in characterizing benign mucosal changes over time.
- Accurate differentiation of benign lesions from early malignancy is crucial in managing gastric conditions.
Related Concept Videos
01:21Barrett Esophagus-I: Introduction
153
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
153
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
168
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
168
01:29Endoscopic Procedures I: Esophagogastroduodenoscopy
299
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
299
01:21Barrett Esophagus-II: Clinical Manifestations and Management
243
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
243
01:24Upper GI Series: Barium Swallow
664
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
664
01:27Gastritis-I: Introduction and Types
641
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
641