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Related Experiment Videos

Nifedipine-induced hyporeactivity in delayed hypersensitivity skin tests.

F Derenne1, M Vanhaeverbeek, D Brohée

  • 1Department of Internal Medicine, C.H.U. André Vésale, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.

International Journal of Immunopharmacology
|January 1, 1987
PubMed
Summary

Nifedipine treatment may suppress the immune system, leading to reduced skin test responses. This study found that nifedipine can induce anergy in delayed hypersensitivity skin tests.

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Area of Science:

  • Immunology
  • Pharmacology

Background:

  • Delayed hypersensitivity skin tests assess cell-mediated immunity.
  • Nifedipine is a calcium channel blocker used to treat hypertension.

Purpose of the Study:

  • To investigate the effect of nifedipine on delayed hypersensitivity skin test responses.

Main Methods:

  • Four patients and three healthy volunteers received delayed hypersensitivity skin tests.
  • Tests were performed before and after one week of nifedipine treatment (10 mg every 8 hours).
  • Antigens used included candidin, tuberculin, streptokinase/streptodornase (SK/SD), and mumps antigen.

Main Results:

  • A decrease in induration and erythema scores was observed after nifedipine treatment.

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  • The reduction in response was particularly notable for the SK/SD antigen.

    • Conclusions:

    • Nifedipine may induce a state of anergy, or reduced immune responsiveness.
    • This suggests a potential immunomodulatory effect of nifedipine on cell-mediated immunity.