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Updated: Aug 6, 2025
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Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
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Factor affecting lymph node metastasis in uterine papillary serous carcinomas: a retrospective analysis
Elif Ceren Tutkun Kilinc1, Vakkas Korkmaz2, Hakan Rasit Yalcin3
1Department of Gynecology and Obstetrics, Sanko University, Gaziantep, Turkey.
Summary
Lymphovascular space invasion (LVSI) and cytology positivity are key predictors of lymph node metastasis (LNM) in uterine serous cancer (USC). These factors are crucial for identifying patients at higher risk for LNM and guiding treatment strategies.
Area of Science:
- Gynecologic Oncology
- Surgical Pathology
- Cancer Research
Background:
- Uterine papillary serous carcinoma (UPSC) is an aggressive endometrial cancer subtype with a high recurrence risk.
- Metastasis patterns in UPSC are complex and not always correlated with traditional prognostic factors like tumor size or myometrial invasion depth.
Purpose of the Study:
- To identify risk factors for lymph node metastasis (LNM) in patients with uterine serous cancer (USC) undergoing systematic staging surgery.
- To evaluate the association between clinicopathological characteristics and LNM in USC.
Main Methods:
- Retrospective analysis of 80 patients with pure uterine serous papillary carcinoma operated on between 2008 and 2020.
- Multivariate analysis to assess demographic and clinicohistopathological factors influencing LNM.
Main Results:
- Lymphovascular space invasion (LVSI) and positive peritoneal cytology were identified as independent risk factors for LNM (p < 0.05).
- 52.5% of patients had no LNM, while 30% had both pelvic and paraaortic LNM.
- Isolated paraaortic lymph node involvement (5% of LNM-positive cases) was 100% associated with LVSI.
Conclusions:
- LVSI and cytology positivity are significant prognostic markers for LNM in USC.
- Cytology positivity remains important, especially in cases with peritoneal spread.
- Isolated paraaortic LNM warrants investigation in patients with positive LVSI.
