Related Experiment Video
Updated: Aug 6, 2025
Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
Published on: January 22, 2020
Relationship between serum fibroblast growth factor 19 and vascular endothelial growth factor and soluble klotho
Yanjun Zhang1,2, Guimei Li3,4, Feifei Xiao2
1Department of Pediatric Endocrinology, Shandong Provincial Hospital, Shandong University, 9677 Jingshi Road, Lixia Area, 250021, Jinan, Shandong, China.
Insights
This study found lower serum levels of Fibroblast Growth Factor 19 (FGF19) and soluble klotho protein (sklotho) in children with type 1 diabetes (T1D), alongside higher vascular endothelial growth factor (VEGF). These factors correlate with HbA1c levels and may influence T1D complications.
Area of Science:
- Endocrinology
- Pediatrics
- Metabolic Disorders
Background:
- Fibroblast Growth Factor 19 (FGF19) plays a role in glycolipid metabolism and may be implicated in type 1 diabetes (T1D) complications.
- Understanding the interplay of FGF19 with other biomarkers is crucial for pediatric T1D management.
Purpose of the Study:
- To evaluate the relationship between serum FGF19, vascular endothelial growth factor (VEGF), and soluble klotho protein (sklotho) in children with T1D.
- To explore potential correlations with diabetes duration and glycemic control (HbA1c).
Main Methods:
- A cross-sectional study involving 66 children with T1D and 30 healthy controls.
- Serum concentrations of FGF19, VEGF, and sklotho were measured using ELISA.
- Participants were analyzed based on T1D duration and HbA1c levels.
Main Results:
- Children with T1D exhibited lower serum FGF19 and sklotho levels, and higher VEGF levels compared to controls.
- FGF19, VEGF, and sklotho levels correlated significantly with HbA1c, but not with diabetes duration.
- Positive correlation found between FGF19 and sklotho; negative correlation between FGF19 and VEGF.
Conclusions:
- Serum FGF19 levels are closely related to VEGF and sklotho levels in pediatric T1D patients.
- FGF19 may contribute to T1D complications in children through interactions with VEGF and sklotho.
Background:
Fibroblast growth factor 19 (FGF19) takes part in maintaining the balance of glycolipids and may be involved in complications of type 1 diabetes(T1D) in children. This study aimed at at evaluating the relationship among the levels of serum FGF19 and vascular endothelial growth factor(VEGF)and soluble klotho protein(sklotho) in type 1 diabetic children.
Methods:
In a cross-section single center study samples were obtained from 96 subjects: 66 T1D and 30 healthy children.Serum FGF19 and VEGF and sklotho concentrations were measured by ELISA. And 66 type 1 diabetes participants were divided into two groups according to T1D duration or three groups according to HbA1c.Furthermore,we compared the serum levels of FGF19 and VEGF and sklotho in different groups.
Results:
The concentration of FGF19 was lower in T1D than in the controls(226.52 ± 20.86pg/mu vs.240.08 ± 23.53 pg/L, p = 0.03),while sklotho was also lower in T1D than in the controls (2448.67 ± 791.92pg/mL vs. 3083.55 ± 1113.47pg/mL, p = 0.011). In contrast, VEGF levels were higher in diabetic patients than in controls (227.95 ± 48.65pg/mL vs. 205.92 ± 28.27 pg/mL, p = 0.016). In T1D, FGF19 and VEGF and sklotho was not correlated with the duration of diabetes. FGF19 and VEGF and sklotho were correlated with HbA1c (r=-0.349, p = 0.004 and r = 0.302, p = 0.014 and r=-0.342, p = 0.005, respectively), but not with blood glucose and lipid. Among subjects in the T1D group, concentrations of FGF19,VEGF and sklotho protein were different between different groups according to the degree of HbA1c(P < 0.005).Furthermore, there was a positive correlation between the serum FGF19 concentration and sklotho levels (r = 0.247,p = 0.045), and a negative correlation between the serum FGF19 concentration and VEGF level(r=-0.335,P = 0.006).
Conclusions:
The serum FGF19 levels have a close relation with serum VEGF levels and sklotho levels among T1D subjects. FGF19 may be involved in the development of complications in children with type 1 diabetes through interaction with VEGF and sklotho.
Related Concept Videos
01:24Regulation of Angiogenesis and Blood Supply
01:22Diabetes Mellitus: Type 2 and Gestational