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Updated: Aug 6, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
B-LBConA: a medical entity disambiguation model based on Bio-LinkBERT and context-aware mechanism
Siyu Yang1, Peiliang Zhang2, Chao Che1
1Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, Dalian University, 116622, Dalian, China.
Background:
The main task of medical entity disambiguation is to link mentions, such as diseases, drugs, or complications, to standard entities in the target knowledge base. To our knowledge, models based on Bidirectional Encoder Representations from Transformers (BERT) have achieved good results in this task. Unfortunately, these models only consider text in the current document, fail to capture dependencies with other documents, and lack sufficient mining of hidden information in contextual texts.
Results:
We propose B-LBConA, which is based on Bio-LinkBERT and context-aware mechanism. Specifically, B-LBConA first utilizes Bio-LinkBERT, which is capable of learning cross-document dependencies, to obtain embedding representations of mentions and candidate entities. Then, cross-attention is used to capture the interaction information of mention-to-entity and entity-to-mention. Finally, B-LBConA incorporates disambiguation clues about the relevance between the mention context and candidate entities via the context-aware mechanism.
Conclusions:
Experiment results on three publicly available datasets, NCBI, ADR and ShARe/CLEF, show that B-LBConA achieves a signifcantly more accurate performance compared with existing models.
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