A novel capsule endoscopy for upper and mid-GI tract: the UMGI capsule

Area of Science:

• Gastroenterology
• Medical Devices
• Endoscopy

Background:

• Complete visualization of the gastrointestinal (GI) tract remains a challenge for existing endoscopy systems.
• A novel upper and mid gastrointestinal (UMGI) capsule endoscopy system was developed using modified detachable string magnetically controlled capsule endoscopy (DS-MCE).

Purpose of the Study:

• To assess the clinical application and efficacy of the novel UMGI capsule endoscopy system.
• To evaluate the technical success, visualization capabilities, examination time, diagnostic yield, compliance, and safety of the DS-MCE system.

Main Methods:

• Thirty patients underwent UMGI capsule endoscopy followed by esophagogastroduodenoscopy.
• Procedures in the upper gastrointestinal (UGI) tract were controlled by magnet and string.
• Key outcomes included technical success, visualization rates, examination duration, diagnostic yield, and safety.

Main Results:

• The UMGI capsule endoscopy achieved 100% detection rates for the Z-line and high rates for the duodenal papilla (80.0%) and pylorus (86.7%).
• String detachment was successful in 96.7% of patients, with a 95.45% complete examination rate of the UMGI tract.
• The system demonstrated a good diagnostic yield (96.2% per-lesion sensitivity for UGI diseases) with high patient tolerance and no adverse events.

Conclusions:

• The developed DS-MCE system offers a viable alternative screening modality for the UMGI tract.
• This capsule endoscopy may be particularly indicated for suspected upper and small bowel GI bleeding.
• Clinical trial registration: NCT04329468.