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Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.

Ashkan Alvand1,2, Abin Kuruvilla-Mathew1,2, Reece P Roberts1,3

  • 1School of Psychology, Faculty of Science, The University of Auckland, Auckland central, Auckland 1010, New Zealand.

Cerebral Cortex (New York, N.Y. : 1991)
|March 17, 2023
PubMed
Summary

Children with auditory processing disorder (APD) show altered brain structural networks at a regional level, impacting listening skills. These findings suggest multimodal deficits and structure-function changes contribute to APD in children.

Keywords:
auditory processing disorderdiffusion MRIgraph theoryrich-clubstructural connectivity

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Neuroimaging

Background:

  • Auditory processing disorder (APD) affects school-aged children with normal hearing.
  • Previous research shows altered functional brain topology in APD using resting-state fMRI.
  • The structural connectome in APD remains underexplored.

Purpose of the Study:

  • To investigate structural brain network differences in children with APD compared to healthy controls (HC).
  • To examine rich-club organization and regional structural connections in APD.
  • To explore structure-function relationships in auditory tasks.

Main Methods:

  • Diffusion MRI data from 58 children (29 APD, 29 HC, ages 8-14) were analyzed.
  • Rich-club organization and edge-wise structural connections were compared between groups.
  • Regional network metrics, including average path length (APL) and betweenness centrality, were assessed.

Main Results:

  • No significant differences in rich-club organization or edge-wise connections were found between APD and HC groups.
  • Children with APD exhibited increased APL in the right inferior parietal lobule and betweenness centrality in the inferior precentral gyrus.
  • Healthy controls showed a positive association between APL and performance on a spatialized noise listening task in the left orbital gyrus.

Conclusions:

  • Structural brain networks are altered at a regional level in children with APD.
  • These alterations suggest the involvement of multimodal deficits in APD.
  • Findings support a role for structure-function alterations in the listening difficulties experienced by children with APD.