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Published on: April 14, 2016
Common Selfcare Indications of Pain Medications in Children
William Zempsky1,2, John Bell3, Vanessa Maria Mossali4
1Department of Pediatrics, Connecticut Children's Medical Center, Hartford, CT, 06106, USA. Wzempsk@connecticutchildrens.org.
Insights
Paracetamol and ibuprofen are common pediatric pain relievers. More research is needed on their use for pain and fever in children with COVID-19 to ensure safe and effective treatment.
Area of Science:
- Pediatric pharmacology
- Pain management
- Infectious disease treatment
Background:
- Pain significantly impacts children's physical function, emotional well-being, and quality of life.
- Pediatric pain conditions like toothache, headache, and respiratory infections are common, often with fever.
- Nonopioid analgesics are primary pharmacologic treatments for pediatric pain, requiring careful dosing.
Purpose of the Study:
- To review pediatric indications, dosing, pharmacokinetics, risks, and benefits of paracetamol and ibuprofen.
- To discuss the role of these analgesics in managing COVID-19 symptoms and post-vaccination effects in children.
- To identify the need for further research on paracetamol and ibuprofen in pediatric COVID-19 management.
Main Methods:
- A narrative literature review was conducted.
- The search focused on pediatric use, dosing strategies, guidelines, and pharmacokinetics of paracetamol and ibuprofen.
- Current evidence on their use in COVID-19 and post-immunization symptom management was also examined.
Main Results:
- Paracetamol and ibuprofen are widely available for pediatric self-care pain and fever management.
- Extensive data exists on their general pediatric use, but specific research for COVID-19 is limited.
- Risks and benefits of these common analgesics in pediatric populations are discussed.
Conclusions:
- Paracetamol and ibuprofen are crucial for symptomatic pain and fever relief in children.
- There is an urgent need for robust studies on their efficacy and safety in pediatric COVID-19 cases.
- Optimizing pain and fever management in children with COVID-19 requires further evidence-based research.
Abstract:
Pain has a multifaceted impact on individuals worldwide, affecting their physical functioning, emotional well-being, and quality of life. Children (age < 18 years) have a high prevalence of conditions associated with pain, such as toothache, headache, earache, sore throat, and respiratory tract infections, many of which may be accompanied by fever. Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects. This narrative review summarizes the findings of a literature search on the pediatric indications, dosing approaches, dosing guidelines, and pharmacokinetics of paracetamol and ibuprofen, which are common pain medications available globally for self-care use in children. The review also discusses the risks and benefits associated with these agents. The current roles of paracetamol and ibuprofen in the symptomatic management of coronavirus disease 2019 (COVID-19) infection and in the management of post-COVID-19 immunization symptoms in children are also discussed. Therefore, while a very large amount of data over several decades is available for paracetamol and ibuprofen, an urgent need exists for well-designed studies of these medications for the management of pain and fever in pediatric patients with COVID-19 to ensure optimal relief with minimal toxicity.
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