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Updated: Aug 6, 2025
08:40
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
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Current research on viral proteins that interact with fibrillarin.
Stefano Decle-Carrasco1, Alma Laura Rodríguez-Piña1, Luis Carlos Rodríguez-Zapata2
1Unidad de Bioquímica y Biología Molecular de Plantas. Centro de Investigación Científica de Yucatán, A.C. Calle 43 No. 130, Colonia Chuburná de Hidalgo, Mérida, Yucatán, México.
Molecular Biology Reports
|March 17, 2023
Summary
Viruses hijack the nucleolar protein fibrillarin (FBL) to disrupt ribosome biogenesis and cellular processes. This review details viral strategies to manipulate FBL, impacting host cell functions.
Area of Science:
- Molecular Biology
- Virology
- Cell Biology
Background:
- The nucleolus is crucial for ribosome biogenesis.
- Viruses manipulate nucleolar proteins, including fibrillarin (FBL), to aid replication.
- FBL is a key methyltransferase involved in ribosomal RNA (rRNA) processing.
Purpose of the Study:
- To review mechanisms viruses use to usurp FBL functions.
- To examine the impact of viral FBL manipulation on cellular processes, especially ribosome biogenesis.
Main Methods:
- Literature review of viral-host interactions focusing on FBL.
- Analysis of molecular mechanisms of FBL usurpation by viruses.
Main Results:
- Viruses induce FBL redistribution within the cell, impairing rRNA processing.
- Viral proteins with intrinsically disordered regions (IDRs) associate with FBL, causing atypical functions.
- FBL manipulation by viruses affects apoptosis and stress responses.
Conclusions:
- Viral usurpation of FBL disrupts ribosome biogenesis and cellular homeostasis.
- Understanding these viral strategies is key to comprehending virus-host interactions.
Keywords:
Animal virusesFibrillarinHuman virusesIntrinsic disordered regionNucleolusRibosome biogenesisMore Related Videos
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