Related Experiment Video
Updated: Aug 6, 2025
07:00
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
5.9K
Top 10 Basaloid Neoplasms of the Sinonasal Tract
Martina Baněčková1,2,3, Darren Cox4
1Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic. baneckova.martina@gmail.com.
Head and Neck Pathology
|March 17, 2023
Summary
Diagnosing basaloid neoplasms in the sinonasal tract requires more than just histology. Advanced molecular and genetic testing, alongside immunohistochemistry, is crucial for accurate identification and management.
Area of Science:
- Pathology
- Oncology
- Head and Neck Surgery
Background:
- Basaloid neoplasms of the sinonasal tract are a diverse group of tumors.
- These tumors share histological similarities but differ in cause, treatment, and outcome.
Purpose of the Study:
- To review the diagnostic challenges of sinonasal basaloid neoplasms.
- To highlight the importance of integrated diagnostic approaches.
Main Methods:
- Literature review of basaloid neoplasms in the sinonasal tract.
Main Results:
- The term "basaloid" describes cells with specific nuclear and cytoplasmic features.
- Sinonasal basaloid tumors range from benign to high-grade malignant, including adenoid cystic carcinoma, NUT carcinoma, and others.
Conclusions:
- Histology may suffice for diagnosis in some cases.
- Limited biopsy or fine-needle aspiration samples present diagnostic challenges.
- Accurate diagnosis often requires a combination of histology, immunohistochemistry (IHC), and molecular genetic testing (DNA/RNA).
Related Concept Videos
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
2.0K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
2.0K
01:27Cranial Bones: Lateral View
2.4K
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
2.4K
01:24Nose and Nasal Cavity
3.3K
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
3.3K
01:03Olfactory Receptors: Location and Structure
9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
01:30Skin Cancer
4.3K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.3K