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Updated: Jul 1, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
An illuminating piece in the jigsaw of Hodgkin lymphoma risk stratification
Ananth Shankar1, Jamshed Bomanji2
1Children and Young People's Cancer Services, University College London Hospitals NHS Foundation Trust, London, UK.
Abstract:
The management strategy of classical Hodgkin lymphoma in children is focussed on maximising therapeutic efficacy while minimising treatment-related toxicity via a risk-adapted and response-based approach. By using volumetric PET parameters, the report of Milgrom and her colleagues shows that combining pretreatment volumetric quantitative PET data with the early response assessment PET2 scan improved risk stratification in children with high-risk classical Hodgkin lymphoma treated on the COG AHOD0831 trial. Commentary on: Milgrom et al. Baseline metabolic tumor burden improves risk stratification in Hodgkin lymphoma: A Children's Oncology Group Study. Br J Haematol 2023;201:1192-1199.
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