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Injection Drug Use and Sexual Risk Behaviors Among People who Inject Drugs in Ukraine: A Random-Intercept Latent

John Mark Wiginton^1,2, Robert Booth³, Lisa A Eaton⁴

¹Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California-San Diego, La Jolla, CA, USA. jwiginton@ucsd.edu.

AIDS and Behavior

|March 17, 2023

Summary

This summary is machine-generated.

A social network intervention reduced HIV risk behaviors among people who inject drugs in Ukraine. Participants moved to safer injection practices, though some transitions still posed HIV acquisition risks.

Keywords:

HIV Latent transition analysis People who inject drugs Social network intervention

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Area of Science:

Public Health
Epidemiology
Social and Behavioral Sciences

Background:

HIV transmission in Ukraine is significantly influenced by unsafe injection drug use and associated sexual risk behaviors.
People who inject drugs (PWID) represent a key population for targeted HIV prevention strategies.

Purpose of the Study:

To analyze behavioral patterns and transitions among PWID in Ukraine within a social network intervention trial.
To identify specific risk behaviors and their association with HIV acquisition.

Main Methods:

Random-intercept latent transition analysis was applied to survey data from 1195 HIV-negative PWID.
Data included 9 binary items on injection drug use and sexual behaviors collected during a clustered randomized clinical trial.
Participants were recruited from Odessa, Donetsk, and Nikolayev, Ukraine.

Main Results:

Five distinct baseline behavioral classes were identified, including 'Social injection/equipment-sharing' and 'Dealer-facilitated injection'.
Intervention participants showed a greater likelihood of transitioning to the 'Collective preparation/splitting' class, characterized by lower risk behaviors.
For control participants, transitioning from 'Collective preparation/splitting' to 'Social injection/equipment-sharing' was linked to increased HIV acquisition risk.

Conclusions:

Social network interventions can shift PWID towards lower-risk behaviors, potentially reducing HIV transmission.
Understanding and targeting specific behavioral transitions are crucial for developing effective, tailored HIV prevention programs.
Further research is needed to confirm the stability of these behavioral patterns and optimize intervention strategies.