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Application of co-processed excipients for developing fast disintegrating tablets: A review
Sajal Jain1, Simrandeep Kaur1, Ritu Rathi1
1Chitkara College of Pharmacy, Chitkkara University, Rajpura, India.
Polimery W Medycynie
|March 17, 2023
Summary
Fast-disintegrating tablets (FDTs) offer improved drug delivery, especially for patients with swallowing difficulties. Co-processed excipients enhance FDT manufacturing by combining multiple functionalities into single agents.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Tablet dosage forms have revolutionized drug delivery.
- Fast-disintegrating tablets (FDTs) are crucial for patients with swallowing issues, offering rapid oral drug release.
- Innovations in FDTs necessitate advanced excipients with superior flow and compression properties.
Purpose of the Study:
- To review fast-disintegrating tablets (FTDs) formulated using co-processed excipients.
- To discuss manufacturing techniques for these advanced dosage forms.
- To highlight recent research, patents, and commercial applications of co-processed FDTs.
Main Methods:
- Literature review of scientific publications and patents.
- Analysis of co-processed excipient properties and their impact on FDT formulation.
- Examination of manufacturing processes for co-processed FDTs.
Main Results:
- Co-processed excipients offer multifunctional benefits, improving flow and compression characteristics for FDTs.
- These excipients simplify the manufacturing process by reducing the number of required components.
- A growing body of research and patent activity indicates significant advancements in co-processed FDT technology.
Conclusions:
- Co-processed excipients are key enablers for the development of advanced fast-disintegrating tablets.
- Their use streamlines manufacturing and enhances tablet performance.
- The field shows dynamic growth with ongoing innovation and commercialization.
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