Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

34.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.8K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding pellet population heterogeneity of Aspergillus niger in stirred tank and rocking motion bioreactors.

Applied microbiology and biotechnology·2026
Same author

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids.

Nature communications·2026
Same author

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.

PLoS genetics·2026
Same author

MicroRNA-mediated neuronal detargeting alters astrocyte cell fate conversion trajectories in vivo.

Communications biology·2025
Same author

REVIVE: a computational platform for systematically identifying rejuvenating chemical and genetic perturbations.

Aging·2025
Same author

A Notch trans-activation to cis-inhibition switch underlies hematopoietic stem cell aging.

Blood·2025
Same journal

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.

Aging cell·2026
Same journal

Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.

Aging cell·2026
Same journal

A Gut-Centric View of Ageing: A Pilot Analysis Mapping Age-Associated Immune and Molecular Alterations in Colonic Mucosa Using Spatial Proteomics.

Aging cell·2026
Same journal

Correction to "Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction".

Aging cell·2026
Same journal

Correction to "Social Stress Shortens Lifespan in Mice".

Aging cell·2026
Same journal

A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX.

Aging cell·2026
See all related articles

Related Experiment Video

Updated: Aug 6, 2025

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.6K

Measuring biological age using a functionally interpretable multi-tissue RNA clock.

Sascha Jung1, Javier Arcos Hodar1,2, Antonio Del Sol1,3,4

  • 1Computational Biology Group, CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, Derio, Spain.

Aging Cell
|March 17, 2023
PubMed
Summary
This summary is machine-generated.

We developed MultiTIMER, a novel tool to measure cellular biological age using gene expression. This aging clock accurately assesses cellular health and response to interventions, aiding rejuvenation research.

Keywords:
agingmachine learningtranscriptomics

More Related Videos

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.5K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Related Experiment Videos

Last Updated: Aug 6, 2025

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.6K
The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.5K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Area of Science:

  • Biogerontology
  • Molecular Biology
  • Computational Biology

Background:

  • Accurate measurement of cellular biological age is crucial for developing rejuvenation strategies.
  • Existing methods often focus on chronological age or single tissues.
  • Understanding cellular aging processes is key to addressing age-related diseases.

Purpose of the Study:

  • To introduce MultiTIMER, the first multi-tissue aging clock for assessing biological age from transcriptional profiles.
  • To evaluate the performance of MultiTIMER in response to cellular stressors and interventions.
  • To identify dysregulated cellular functions associated with aging.

Main Methods:

  • Development of MultiTIMER, a computational tool analyzing transcriptional profiles.
  • Application of MultiTIMER to over 70,000 transcriptional datasets across multiple tissues.
  • Validation of MultiTIMER's accuracy against known cellular aging markers and responses.

Main Results:

  • MultiTIMER accurately quantifies cellular biological age, distinguishing it from chronological age.
  • The aging clock demonstrated sensitivity to various cellular stressors and known rejuvenation interventions.
  • Analysis revealed specific dysregulated cellular processes linked to biological aging.

Conclusions:

  • MultiTIMER provides a robust method for measuring biological age across multiple tissues using gene expression data.
  • This tool can accelerate the discovery and validation of novel rejuvenation strategies.
  • MultiTIMER offers insights into cellular aging mechanisms and potential therapeutic targets.