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Updated: Aug 6, 2025
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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
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Vascularized organ bioprinting: From strategy to paradigm
Heran Wang1,2,3, Xin Liu4, Qi Gu4
1State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China.
Cell Proliferation
|March 17, 2023
Summary
3D bioprinting shows promise for creating vascularized organs. This review proposes a bidirectional strategy and new research paradigms to overcome challenges in integrating multi-technology for advanced biomedical applications.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- 3D bioprinting is a leading technology for in vitro vascularized organ manufacturing.
- Significant challenges remain in interdisciplinary knowledge and multi-technology integration for clinical translation.
Purpose of the Study:
- To review vasculature manufacturing goals and propose strategic objectives.
- To outline a bidirectional manufacturing strategy integrating bioprinting and cellular regeneration.
- To introduce novel research paradigms for future advancements.
Main Methods:
- Review of current 3D bioprinting literature and strategies.
- Analysis of design, bio-ink, printing, and culture aspects.
- Proposal of 'construction-comprehension cycle' and 'math-model-based batch insights generator' paradigms.
Main Results:
- Identification of key challenges in 3D bioprinting for organ manufacturing.
- Development of a bidirectional manufacturing strategy (top-down and bottom-up).
- Introduction of innovative research paradigms to guide future development.
Conclusions:
- A strategic, bidirectional approach is crucial for advancing 3D bioprinting.
- Novel research paradigms may revolutionize organ manufacturing and biomedical applications.
