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Reversal of ethylene glycol-induced nephrotoxicosis in a dog
L E Fox1, G F Grauer, R R Dubielzig
1Department of Medical Sciences, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Journal of the American Veterinary Medical Association
|December 1, 1987
Abstract:
Ethylene glycol-induced nephrotoxicosis was diagnosed in a dog with acute renal failure. Histologically, the dog had proximal tubular degeneration and necrosis, intraluminal calcium oxalate crystals, generally intact tubular basement membranes, and evidence of tubular regeneration. After 20 days of peritoneal dialysis and diuresis, renal function was adequate to maintain homeostasis without supportive care. Nine weeks after onset of the ethylene glycol-induced renal failure, the dog's kidneys were histologically and functionally normal.